I can usually open about 4-5 different programs and then PCDMIS completely crashes. The programs aren't open at the same time. I'll open one, run, edit, or nothing, close it and then open up a new one that I need to work on. After about 3-5 times PCDMIS crashes and I have to restart the entire computer to get PCDMIS to start up again.
I vaguely remember something like that being a precursor to a hard drive failure on an old manual brown and sharp CMM at my old job. Maybe check the system logs and see if something in the computer is causing an issue.