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PC-DMIS Software program

Hi,
I want to write a program for a Assembly. I would be writing the program using the CAD model and then execute that program to measure the part.
The first thing would be defining the datum’s. My part would be loaded on the fixture. Once I execute the program, I won't be able to access the datum points to probe them as the part is on the fixture. SO how to I probe the datums on the actual part.