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The reason of orient to zpoint-xpoint

Hello Everyone,
 
Could some one help to make me my two thoughts clear.
 
first:
We can only chose (orient to zpoint-xpoint ) to make the dependency of orientation, but never zpoint-ypoint.
Is the reason that the Euler angle should be 313, it means rotation about ZXZ? There may be a singular result if the y-angle in n*180deg .
 
second:
For example. I want to make the y-direction of the construction frame( cm-marker, inertia_frame marker) as the axial-axis of steering column part with forced. There may be occur error in particular orientation during simulation?
 
Thanks a lot
Zhenhui Xu​