The load cases at least for static condition may not be very difficult. You an create hydrostatic pressure loads, based on submerged depth of the yacht shape and displaced fluid based on the total weigh (including loaded cargo.)
What would be the most dramatic static loads I should include. Should we study the yacht with the hull fully submersed in water, and not really horizontal but the front a higher than the back?
It would depend on the design requirement. Generally larger amount of submersion should produce higher loads. The weight distribution will dictate the orientation of the Yacht in the fluid. One would also will have to consider loading under operational condition and could be very drastically different. These data can be generated from fluid codes. SC/Tetra may have some functionality to determine these loadings. www.cradle-cfd.com/.../
I think a crucial first step is buying an actual yacht, to do "real world" testing...probably would require a few months of intense yacht excursions, probably to the Carribean, Hawaii, etc.). I assume you just submit a normal expense report to MSC to reimburse you for the yacht purchase, along with other essentials (e.g., suntan lotion).