The top Pattern Locating Tolerance Zone Framework (PLTZF) locks all rotations and origins in accordance to the datums. The bottom Feature Relating Tolerance Zone Framework (FRTZF) is allowed to tilt\rotate or shift within the confines of the PLTZF. Normally, The FRTZF controls orientation only to specified datums but, in this instance no Datum is specified so... no control. Build the PLTZF alignment and report position. Then use that same alignment to build a Best fit with the two holes and release all degrees of freedom and report the best fit position.