Losing Calibration Results

Might be corrupted. Delete the probe file, recreate it, then recalibrate it. 

Several all at once though? That's why I didn't go for that right away

Sounds more like a permissions problem to me.

I run PC-DMIS as admin. Could that still cause permission problems.

It's normally the inverse.  Where are you storing your probe files?  Are they in the default location (C:\Users\Public\Documents\Hexagon\PC-DMIS\version)?

No I created a Probe Directory folder on our network (Quality Assurance\Global S PC-DMIS Directory\Probe Directory)

That's most probably the issue then.  Either the PC-DMIS application itself, or the user account you are running under doesn't have full read/write permission for that network location.  F.Y.I storing probe files on a network is not recommended.  Aside from the permissions related problems that can arise, you can also have problems if the connection drops.  Furthermore, if you have multiple machines they ABSOLUTELY MUST store probe files locally.  Having multiple machines accessing the same file at the same time is extremely bad.  It will lead to nonsense measurement results, corrupted files and potentially crash machines.

That's most probably the issue then.  Either the PC-DMIS application itself, or the user account you are running under doesn't have full read/write permission for that network location.  F.Y.I storing probe files on a network is not recommended.  Aside from the permissions related problems that can arise, you can also have problems if the connection drops.  Furthermore, if you have multiple machines they ABSOLUTELY MUST store probe files locally.  Having multiple machines accessing the same file at the same time is extremely bad.  It will lead to nonsense measurement results, corrupted files and potentially crash machines.

I have a Probe folder for each CMM on the network to avoid that. I do think im going to move them to their own computers though.