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clearance cube yes or no??

So I have always used a clearance cube when programing. I do understand it may slow the run time down a bit, but feel it is safer to use it then not. However The guy I replace did not ever use them in any program. He has move points everywhere. It got me to a thinkin what is the best way to use them or not to use them???

Also when I go to add the CC to his programs it seems to mess them up and they do not run correctly. Why would this be?