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Offline vs. Online Programing

Question;
I am using PC-DMIS 4.3
When I write a program offline from a cad model all seems well.
I try to run it on the visio 300 and end up having to redo the manual stuff in order to run the program.
The manual surface points are off and th machine cant focus also on the edge points it wont find the edge.
I think i ma have a setting rong.

Thanks